Anti-TB dose ‘BPaL’ gets global approval

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Anti-TB dose ‘BPaL’ gets global approval

Small anti-tuberculosis dose Anti-TB dose ‘BPaL’ has received global approval if a recent test is ‘positive’.

A short-term treatment of six months called BPaL has shown favorable results in patients with tuberculosis (TB).

क्षय रोग-रोधी खुराक 'BPaL' को वैश्विक मंजूरी मिली

BPaL is a 6-monthly dosed treatment. It is an oral drug and is a three-drug dosage.

It is used to treat patients suffering from highly drug-resistant forms of tuberculosis.

BPaL is a combination of three new antibiotics. These three medicines are: bedaquiline, pretomanid, and linezolid.

TB Alliance’s BPaL drug has reduced the treatment time of tuberculosis from 18 months to 6 months. Also, the reported success rate is 90%. This rate can prove to be important in the eradication of tuberculosis. (The TB Alliance is a non-profit organization.)

Drug-resistant tuberculosis occurs when bacteria develop resistance to the drugs used to treat tuberculosis.

Types of drug resistant tuberculosis

  • Mono-resistance: Resistance to first-line anti-tuberculosis drugs only.
  • Poly-resistance: Resistance to more than one first-line anti-tuberculosis drug excluding isoniazid and rifampicin drugs.
  • Multi-drug resistance (MDR): Develops resistance to at least both isoniazid and rifampicin.
  • Extended drug resistance (XDR): Resistance against any fluoroquinolone other than MDR, as well as resistance against at least one of the three second-line injectable drugs (capreomycin, kanamycin and amikacin).
  • Rifampicin resistance (RR): Resistance to rifampicin drug in the form of single-resistance, multiple-resistance, MDR or XDR.

Tuberculosis (TB)

  • Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis, which most often affects the lungs. It can also affect other organs.
  • Most common drugs used to treat tuberculosis include isoniazid, rifampin, ethambutol, pyrazinamide, etc.
  • BCG is currently the only licensed vaccine available for the prevention of tuberculosis.

Source- The Hindu

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